Ultrasound Made Me the Doctor I Wanted to Be

I didn’t come into medicine knowing much about what doctors really did. I also didn’t graduate my emergency medicine residency really believing point-of-care ultrasound (POCUS) was all that useful. Maybe it’s just a fad, I remember thinking.Minardi, Joseph J.

There were two things I did come to enjoy about medicine: making interesting diagnoses and intervening in ways that helped patients. Those were the victories and they were always more satisfying when I got to do them as independently as possible. It was great to diagnose appendicitis with a CT scan, but I had to share at least some of the credit with the radiologist.

I remember sometimes being frustrated with the fragmentation of care in American medicine. Send the patient to another facility with these services, order this imaging study by this specialist, consult this specialist for this procedure, and so on.

A few cases early in my career really brought to light these frustrations.

One was a young woman who didn’t speak English who presented to our community hospital who appeared to have abdominal pain. It took hours after getting approval to call in a sonographer, consulting with the radiologist, and eventually calling in the gynecologist from home to take her to the operating room for her ruptured ectopic pregnancy. Hours went by while her condition worsened and I felt helpless, being uncertain about her diagnosis and relying on fragmented, incomplete information from others to make management decisions. Luckily, her youth allowed her to escape unscathed, but I was frustrated with what I didn’t know and couldn’t provide for her: a rapid, accurate diagnosis and quick definitive action.

In another case, a young boy was transferred to our tertiary care center for possible septic hip arthritis and waited nearly 24 hours to undergo more ED imaging, subspecialty consultation, then wait for the availability of the pediatric interventional radiologist to perform X-ray guided hip aspiration with procedural sedation. I remember again feeling helpless and seeing the hopelessness in the eyes of his parents after seeing so many doctors, spending so many hours far from home just waiting on someone to tell them what was wrong with their son and what was going to be done to help him.

After I was asked to lead POCUS education for our residency program and began to embrace it as a clinical tool, I encountered similar cases, but now with much more satisfying experiences for me as a physician, and hopefully, presumably for my patients. Now, I routinely hear stories from my residents and colleagues that go something like Hey Joe, check out this ectopic case, ED to OR in 20 minutes with bedside ultrasound. We have had cases of suspected hip arthritis where we were able to provide a diagnosis and care plan from the ED in 2–3 hours by performing bedside US-guided hip arthrocentesis. These and numerous other cases where diagnoses are made in minutes independently by the treating clinician have convinced me that POCUS can help improve healthcare. My colleagues and I have performed diagnostic and therapeutic procedures that we never would have considered attempting before we could competently use POCUS, allowing us to provide immediate care right where and when the patients needed it.

The “passing fad” of POCUS has allowed me to make medicine and being a doctor more into what I wanted it to be: seeing patients, giving them a diagnosis, decreasing the anxiety over uncertainty, and providing relief for their suffering. I trained and practiced without the advantages of ultrasound and I have seen the positive impact it can have not only on patients but also on the health care system and my job satisfaction as well. The advantages of more immediate, efficient diagnoses, better availability of advanced procedures can all be provided in a less fragmented, more cost-effective manner when treating clinicians are armed with and properly trained to use POCUS. There’s no way I would ever go back.

If you learned how to use ultrasound after you completed your original medical education, how did it affect your career? Comment below or let us know on Twitter: @AIUM_Ultrasound.

Joseph J. Minardi, MD, is Chief of Emergency and Clinical Ultrasound, and Associate Professor of Emergency Medicine and Medical Education at the West Virginia University School of Medicine.

Ultrasound in Orthopedic Practice

Point-of-care ultrasound brings great value to patient care in orthopedic practice, especially for soft tissue problems. It offers safe, cost-effective, and real-time evaluation for soft tissue pathologies and helps narrow down the differential diagnosis.Pic1

There are a variety of soft tissue lesions in orthopedic practice with a classic clinical presentation that may not necessitate ultrasound examination for confirmation of diagnosis, for example, ganglion cyst. However, there is value in performing an ultrasound scan for these common soft tissue lesions.

Ganglion cyst on the dorsum of the wrist or radial-volar aspect of the wrist are confirmed based on clinical examination and presentation. Adding ultrasound examination can help differentiate classic ganglion cyst from some rare findings like Lipoma, anomalous muscles, or soft tissue tumors. Ultrasound examination may also be helpful in finding the source of the ganglion cyst or the stalk of the ganglion cyst. This can help pre-surgical planning if resection of the ganglion cyst is desired by the patient and recommended by the surgeon, because arthroscopic or traditional surgical approach may be needed based on the location of the stalk or neck of the cyst.

Images 1 and 2 show examples of two different patients with a similar presentation of slow-growing mass on the digit. Image 1 from patient 1 shows a solid tumor overlying the flexor tendons of the digit, where the mass was palpated. Image 2 from patient 2, shows a cystic mass overlying the tendons of the digit. In both of the cases, masses were painless and slow growing with minimal to no discomfort. Ultrasound is a great tool in differentiating solid vs cystic lesions and can help avoid attempted aspiration of a solid mass when the mass is presented in an area of classic ganglion cyst’s usual presentation.

Another soft tissue problem, where ultrasound is a superior imaging tool is tendon pathology. Ultrasound can help differentiate tendinosis, tenosynovitis, or tendon tears.

In tenosynovitis, tendon by itself shows normal echotexture and uniform appearance but the tenosynovium that surrounds the tendon gets inflamed and appears as hypoechoic halo around the tendon, for example, in image 3, tendons of the first dorsal compartment of the wrist show uniform thickness and fibrillar echotexture, however there is hypoechoic swelling around the tendons, this is an example of tenosynovitis of first dorsal compartment of the wrist.

In tendinosis, tendon loses its fibrillar pattern and appears swollen and may show vascularity on color ultrasound, which is suggestive of neoangiogenesis or angiofibroblastic proliferation. For example, in Image 4, the tendons of the first dorsal compartment of the wrist show focal enlargement, hypoechoic swelling, and loss of normal fibrillar echotexture and tendon appears disorganized with evidence of increased vascularity on color ultrasound. This is an example of tendinopathy or tendinosis.

Focal tendon tears appear as anechoic or hypoechoic focal defects in tendon substance. Image 5 shows a partial tear of the triceps tendon from the olecranon process. The partial tear appears as a focal hypoechoic defect in the tendon, which is confirmed in the long and short axis scan of the tendon.

In full-thickness tears, the tendon is seen retracted proximally with no fiber attachment at the tendon footprint. Image 6 shows an example of a full thickness complete tear of the supraspinatus tendon from its bony attachment at the greater tubercle. The tendon has retracted proximally and the retracted stump is not visible on ultrasound examination.

Image 6

Point-of-care ultrasound adds significant value to clinical examination in an orthopedic setting. It enhances the understanding of a patient’s problem, increases confidence in the care provided, and high patient satisfaction is reported.

In what unexpected ways do you find ultrasound to be useful? Do you have additional tips for using ultrasound in orthopedics?  Comment below or let us know on Twitter: @AIUM_Ultrasound.

Mohini Rawat, DPT, MS, ECS, OCS, RMSK, is program director of Fellowship in Musculoskeletal Ultrasonography at Hands On Diagnostics and owner of Acumen Diagnostics. She is ABPTS Board-Certified in Clinical Electrophysiology; ABPTS Board-Certified in Orthopedics; registered in Musculoskeletal Sonography, APCA; and has an added Point-of-Care MSK Soft Tissue Clinical Certificate.

Pre-eclampsia, Growth Restriction, and a Placenta Bank

Our Maternal-Fetal Medicine fellow was talking about a delivery that occurred while I was away. The fetus was growth-restricted and developed worsening indices on Doppler ultrasound of the umbilical arteries. What was initially an increased Systolic/Diastolic ratio became first absent and then reversed end-diastolic flow. As this occurred over several weeks, the patient herself had worsening blood pressures and symptoms related to her pre-eclampsia and the fetal tracing became more concerning. She was ultimately delivered and her tiny and premature baby was now in the care of the neonatologists.201500581_Hill-7

The fellow’s presentation focused on the ultrasound findings and the surveillance of pregnancies that become complicated in this way. What was known was the best current management in this case. The unknown was why this had happened in the first place. I was about to interrupt the presentation when our fellow, knowing what I was going to ask, looked over at me and said “Yes, I did collect the placenta.”

Pre-eclampsia is a common condition and growth restriction, by definition, occurs in 10% of pregnancies. The conditions are highly related. We have risk factors for both, but we seldom know the cause. Our treatments seem crude to a bench researcher; try to control the condition as long as you can, and if either patient or her fetus becomes too sick, deliver the pregnancy.

As an obstetrics and gynecology resident, I was fascinated by developmental programming in these fetuses and sent in a grant application to the American Institute of Ultrasound in Medicine requesting seed funding to look at the hormonal associations with growth restriction. Their contribution to my research was a turning point for me. I had always thought of myself as a clinical researcher and this was my first exploration of translational research. During my fellowship in Maternal-Fetal Medicine, I collected ultrasound data on growth restricted pregnancies and sampled placentas and cord blood from the pregnancies when they delivered. What I had thought would be a one-off project became a jumping off point for continued exploration into placental biology.

Five years later, I have established a placenta bank at the University of Arizona. What was a small study focusing on just one condition has inspired the creation of a bigger project. Our residents and fellows now contribute to the bank and have the ability to answer their own questions with the samples already collected. The bank is a resource to all of us and has fostered collaborations with the University of Arizona Biorepository and the department of Animal and Comparative Biomedical Sciences. My initial work focused on changes in leptin, renin, and C-reactive protein in cord blood, but as I learned more, the objective changed to include RNA analysis of the placental tissue. We noted that the structural protein expression was different in the growth-restricted pregnancies. This has led to the proposal of a whole different model regarding the causation of preeclampsia and growth restriction.

We will wait and see how this baby does in the neonatal intensive care unit. As we go about our conservative management until the risk becomes too great to continue, it is a comfort to know we are looking for reasons; if we understand possible mechanisms better, there is the potential to mitigate or reverse the development of fetal and maternal morbidities.

How has ultrasound shaped your career? Has an ultrasound study led you down an unexpected path? Comment below or let us know on Twitter: @AIUM_Ultrasound.

Meghan Hill, MBBS, is Assistant Professor at The University of Arizona College of Medicine, Department of Obstetrics & Gynecology.

Storing Blood as a Dry Powder

Did you know that blood can only be stored for up to 6 weeks when refrigerated? Because synthetic blood is not available in the clinic, blood supplies must be continually replenished from healthy donors. Even if there is a surge in blood donations at one point in time, 6 weeks later there could be shortages if continued donations do not meet the current demand. Blood can be frozen for a decade or more but significant challenges in processing blood for frozen storage limit this option to specific situations such as for rare blood types or military use. The freezing process currently utilizes high concentrations of glycerol to protect red blood cells during frozen storage but this compound must be removed prior to transfusion, and the de-glycerolization process is very sensitive and time-consuming. Therefore, most hospitals and medical centers utilize refrigeration for blood storage.

What if, instead of refrigerating or freezing blood, there was a method to freeze-dry blood for long-term storage as a dry powder, similar to the process used for astronaut food? This could enable long-term blood storage at room temperature, and when the blood is needed for transfusion the cells could be quickly reconstituted simply by adding sterile water. Not only would this offer another option for long-term storage, it would be particularly useful in situations where refrigeration or freezing is not available, such as in some remote medical centers or for the military in far-forward settings. In addition, this method could enable stockpiles of strategic blood reserves in order to maintain an adequate blood supply during disasters such as hurricanes, which disrupt blood donations.

Blood cells dried

Electron microscopy image of red blood cells after drying/rehydration following ultrasound-mediated loading with preservative compounds.

The idea of turning blood into a dry powder and then rehydrating it for transfusion may sound like science fiction, but could it become a reality? Can nature provide clues to help us solve this problem? There are many cases in history where significant scientific breakthroughs were achieved by studying nature. For example, the Wright brothers studied the characteristics of birds’ wings during flight to discover an effective design for airplane wings. Also, Alessandro Volta invented the battery after carefully studying the electric organ in torpedo fish. In the context of cell preservation, it has been found that some organisms can survive complete desiccation for long periods of time. For example, tardigrades and brine shrimp (“water bears” and “sea monkeys”) can be dried out and remain in a state that approaches “suspended animation” for decades, but when they are rehydrated they return to normal physiological function and can even reproduce. This led us to ask the question, if these complex multicellular animals can survive desiccation, why not individual red blood cells? Scientists have found that these organisms produce protective compounds, including certain sugars and proteins, which prevent damage to their membranes during drying and rehydration.

Unfortunately, human cells do not have the transporters in their membranes that enable internalization of the protective compounds found in organisms that can survive desiccation. Therefore, an active loading method is required. We realized that the process of ultrasound-mediated drug delivery via sonoporation could potentially be applied to solve this problem and enable delivery of protective compounds into human red blood cells. In the past, most ultrasound research has either ignored red blood cells or attempted to minimize sonoporation in these cells. But what if we could intentionally sonoporate red blood cells outside of the body in order to actively load them with protective compounds so that they could be stored as a dry powder at room temperature until needed for transfusion?

Our initial efforts to load red blood cells with protective compounds for storage as a dry powder have been promising. We prepared solutions containing red blood cells, preservative compounds, and microbubbles followed by treatment with B-mode ultrasound for ~60 seconds. After ultrasound treatment, the cells were freeze-dried and stored as a dried powder at room temperature (21–23 °C) for 6 weeks or longer. Cells were rehydrated with water and we measured up to 30% recovery of viable red blood cells. In addition, we performed electron microscopy imaging of the rehydrated red blood cells and observed evidence of normal biconcave-discoid shape. Our next steps involve testing the rehydrated cells in an animal model of acute hemorrhage in order to assess the function and safety of the red blood cells in vivo after dry storage at room temperature.

Research studies are currently ongoing and much more work remains to be done before clinical translation is possible, but if it is successful this approach could have a significant impact on blood supply, particularly in locations where refrigeration and freezing are not available. In addition, this approach could potentially enable dry storage of other cell products. As I consider the possibilities of this approach, I wonder if there are other things that we can learn from nature that could also transform medical practice.

Have you learned something else from nature that has been incorporated into your medical practice? Do you have any ideas that could potentially transform medical practice? Comment below or let us know on Twitter: @AIUM_Ultrasound.

Jonathan Kopechek is an Assistant Professor of Bioengineering at the University of Louisville. His Twitter handle is @ProfKope.

Real-time Ultrasound in Physical Therapy

In the past 20 years, there are very few pieces of equipment I can say unequivocally changed how I practice as a physical therapist (PT); without question, real-time ultrasound (RTUS) is one. A sports/orthopedic colleague introduced RTUS to my practice 8 years ago. As a pelvic PT, I thought it would be a nice adjunct to my current practice with biofeedback, exercise, and manual techniques. I was wrong. It was a game changer. What initially started out as an exercise in interpreting black & white ink-blot-like images has evolved into so much more.Lisa-Damico-Portraits-Carrie-Pagliano-0413-LOW-RES

For those unfamiliar with pelvic floor physical therapy, typical pelvic floor assessment, without RTUS, includes an external assessment of the perineal region. Frequently, internal digital assessment is used to identify pelvic floor muscle strength, endurance, coordination, tender points, and presence of pelvic organ prolapse. Biofeedback assessment can give a general sense of local muscle activity, via either internal or external electrodes. Absent from this data collection, however, is the ability to assess function. What is the effect of pelvic floor activity on the bladder? What specific muscles in the pelvis and abdomen are activating and when? What do you do when a patient is unable to tolerate an internal assessment? RTUS addresses all of these questions. Via a transabdominal approach, I am able to assess the function of pelvic, abdominal, hip, and back musculature in the context of breath and movement. I am able to make an assessment without an internal approach, which may be threatening or uncomfortable for patients with pelvic pain. I am able to determine the function of the pelvic floor and its effect on the bladder and urethra as well.

My practice includes RTUS primarily for evaluation of movement of the pelvic floor, abdominals, hip, and spine. The primary goal is to find and address neuromuscular dysfunction in the context of urinary/fecal incontinence, pelvic pain, diastasis recti, and pelvic girdle pain. Beyond helping me identify inefficient movement strategies, coordination variances, and relevant dysfunction, RTUS has been an enormous help in educating my patients about their own bodies and how they function. I never anticipated how much a little black and white image would help patients make this connection! For example, many people have no idea where their pelvic floor is, much less what its relationship is to their bladder, pelvis, or breath. With just a quick look at the screen and a little orientation, RTUS can give patients a window into the simple yet complex connections within their own bodies.

The most striking patient activity with RTUS is using imaging to show the relationship between breath and the pelvic/abdominal region. Patients who are visual learners especially find this an invaluable tool. I use focused exhalation (cued blowing through a straw), vocalization, and varying volumes and octaves to get automatic activation of transverse abdominal and pelvic floor musculature. Patients see, in real time, the effect of their breathing (or breath-holding) strategies have on activation of muscles in the pelvic region. Patients no longer have to try to cognitively process how to turn these muscles on or off (which is laborious and practically impossible to be consistent), but rely on something as simple as breath to assist in activating or relaxing their muscles.

As you can see, RTUS provides both patients and clinicians a window into the pelvic region, providing additional insight into the patient’s function and dysfunction. Having AIUM recognize physical therapists in the AIUM Practice Parameter for the Performance of Selected Ultrasound-Guided Procedures is an outstanding step toward including PTs in this area of practice. I’ve been privileged to work alongside physical therapists working in the area of RTUS education, facilitated diagnostics and real-time needle tracking within our profession. I’m excited that the area of pelvic physical therapy is being included in using RTUS in progressive physical therapy practice. I am looking forward to more integration of RTUS in physical therapy patient care as well as physical therapy education! The more physical therapists have knowledge and skill using this unique tool, the more comprehensive care and outcomes PTs can provide!

Have you included real-time ultrasound in your physical therapy practice? If so, how has it impacted your practice? Comment below or let us know on Twitter: @AIUM_Ultrasound.

Carrie Pagliano, PT, DPT, MTC, is a Board Certified Women’s Health & Orthopaedic Clinical Specialist and is owner of Carrie Pagliano PT, LLC, in Arlington, VA.

Sonographers and Contrast-Enhanced Ultrasound

Now that contrast-enhanced ultrasound (CEUS) has been approved in the United States for several abdominal applications in adults and pediatrics, I decided to take a deeper look into the sonographer’s role in CEUS. Traditionally, sonographers perform ultrasound examinations based on a protocol, construct a preliminary ultrasound findings worksheet, and perhaps discuss the findings with a radiologist. And now CEUS has transformed traditional ultrasound and gives physicians and sonographers additional diagnostic information related to the presence and patterns of contrast enhancement.DSC00125

Based on sonographers’ traditional scope of practice, some questions came to mind. What is the training process for sonographers to learn CEUS? How should CEUS images be obtained and stored? How should CEUS findings be communicated?

I envision CEUS training for sonographers broken down into stages, where they begin by learning the basics and eventually transition to where they can perform and record the studies independently. The first stage for sonographers is the ‘CEUS learning curve.’ In this stage, sonographers become familiar with basic CEUS concepts, eg, understanding physics of contrast agents and contrast-specific image acquisition modes, CEUS protocols, and typical patterns of contrast enhancement seen in various organs. In addition, an important part of the training is recognizing contrast reactions, and learning IV placement, documentation and billing related to CEUS.

The next stage involves sonographers performing more patient care and gaining scanning responsibilities. Sonographers place the IV and prepare the contrast agent. The scope of sonographer responsibilities does not generally include contrast injection (although it is reasonable since CT, MR, nuclear medicine, and echocardiography technologists routinely place IV lines and inject contrast). It should be noted that CEUS examination usually requires an additional person (physician, nurse, or another sonographer) to assist with contrast injection while the sonographer performs the ultrasound examination. In the beginning of sonographer training, it is very beneficial to have a radiologist present in the room to guide scanning and appropriate image recording.

In the third stage, a well-trained sonographer is more independent. At the completion of the examination, the sonographer will either send clips or still images to a physician to document the CEUS findings and discuss the procedure. Ideally, a worksheet is filled out, comparable to what is done today with “regular” ultrasound.

The majority of CEUS examinations are performed based on pre-determined protocols, usually requiring a 30–60-sec cineloop to document contrast wash-in and arterial phase enhancement. After that continuous scanning should be terminated and replaced with intermittent acquisition of short 5–10-sec cineloops obtained every 30–60 sec to document late phase contrast enhancement. These short clips have the advantage of limiting stored data while providing the interpreting physician with real-time imaging information. Detailed information on liver imaging CEUS protocols could be found in the recently published technical guidelines of the ACR CEUS LI-RADS committee.[i] Some new users might acquire long 2–3-minute cineloops instead, producing massive amounts of CEUS data. As a result, studies can slow down a PACS system if departments are not equipped to deal with large amounts of data. In addition, prolonged continuous insonation of large areas of vascular tissue could result in significant ultrasound contrast agent degradation limiting our ability to detect late wash-out, a critical diagnostic parameter required to diagnose well-differentiated HCC. Any solution requires identifying and capturing critical moments, which will be determined by a sonographer’s expertise. Exactly how sonographers can ensure CEUS will successfully capture the most important images is a critical question that must be answered and standardized.

Ideally, leading academic institutions should provide CEUS training for physicians and sonographers. I have seen and attended CEUS continuing medical education courses and they are a great way for physicians and sonographers to learn CEUS imaging. CEUS is a step forward for sonographers and will potentially transform our scope of practice. The technology will advance the importance of sonographers and diagnostic ultrasound, and importantly it will improve the care of our patients.

Acknowledgements:
Dr. Laurence Needleman, MD
Dr. Andrej Lyshchik, MD
Dr. John Eisenbrey, PhD
Joanna Imle, RDMS, RVT

[i] Lyshchik A, Kono Y, Dietrich CF, Jang HJ, Kim TK, Piscaglia F, Vezeridis A, Willmann JK, Wilson SR. Contrast-enhanced ultrasound of the liver: technical and lexicon recommendations from the ACR CEUS LI-RADS working group. Abdom Radiol (NY). 2017 Nov 18. doi: 10.1007/s00261-017-1392-0. [Epub ahead of print]

Has CEUS helped your sonography career? How do you envision CEUS being incorporated in your work? Comment below or let us know on Twitter: @AIUM_Ultrasound.

Corinne Wessner BS, RDMS, RVT is the Research Sonographer for Thomas Jefferson University Hospital in Philadelphia, Pennsylvania. Corinne has an interest in contrast-enhanced ultrasound, ultrasound research, medical education, and sonographer advocacy.

How to Commercialize Ultrasound Technology

A few years ago, I had the opportunity to commercialize an ultrasound technology. Reflecting upon this process, I am very grateful that there were so many team members and things (including those beyond our control) that contributed to the success of the project. By sharing our journey from the research bench to public use, I hope that people will get an idea of what is involved in a commercialization process and appreciate the importance of team work.Chen_Shigao_2016

It started with our research team who sketched out an idea of using multiple push beams spaced out like a comb to generate multiple shear waves at the same time. It could be used to improve both signal-to-noise ratio and the frame rate for ultrasound elastography. Fortunately our lab had a research scanner that came with a programmable platform. This idea was prototyped and tested on the same day and it worked! Were it not for the research scanner, it would have taken months to get this done. The alternative process involves contacting an ultrasound company (if we ever find one), gaining their support (a research agreement could take months to reach), and testing on a commercial prototype scanner (which is much harder compared to using a research scanner).

It was soon discovered afterwards that the interference of shear waves from the comb push beams make it very hard to calculate the wave speed for elasticity imaging accurately. A mathematician in our team offered to apply a signal processing algorithm that detangles the complicated shear waves into simpler component waves. It solved our problem and helped the idea pass the initial functionality test. The next step was to show the industry the translational potential of this technology and out-license it to them for further development and testing.

Back then, the clinical ultrasound division at our institution was developing a strategic partnership with a leading ultrasound company, which was looking for a shear wave elastography solution for their products. The company soon decided to license our technology. To speed up the progress, our intellectual property (IP) office negotiated the licensing agreement with the company, while we worked with the company engineers on the technology in parallel. Both parties shared a common culture of openness, which allowed us to exchange codes with each other. This trusting relationship was found to be very beneficial by both sides as we shared the dedication to achieve common goals quickly.

To ensure the successful implementation of the prototype, the collaboration continues in the form of site visits and numerous teleconferences between the sites until satisfied phantom and in vivo results were yielded. When the near-end prototype was available, an independent clinical study was performed at our institution to verify the performance and establish cut points for liver fibrosis staging. It greatly exemplified the benefit of affiliating with a large medical center. The extensive interdisciplinary research and medical environment at our institution has provided a unifying framework that bridges the gap of technical creation and clinical deployment. Upon positive results from clinical trials, the company was able to launch the product in 2014. The technique was FDA-approved and released at RSNA. We are very pleased to see the research outcome has been taken from the bench to the bedside and is improving the effectiveness of patient care worldwide.

It truly takes a village to make this happen. The success came with the supports of a huge team of ultrasound physicist, PhD student, mathematician, study coordinator, sonographer, radiologist, IP staff, and licensing manager. It calls for an industrial partner that has shared appreciation of value and common core objectives. Looking back at our journey, it is without question that every step presents its own challenge. By sharing our experiences, we hope to contribute to your future successful technology commercialization.

Have you tried to commercialize an ultrasound technology? Have you had a different experience commercializing ultrasound technology? Comment below or let us know on Twitter: @AIUM_Ultrasound.

Shiago Chen, PhD, is a Professor at the Department of Radiology, Mayo Clinic College of Medicine.